Status:
COMPLETED
Robotic Assessments of Hand Function in Patients With Parkinson's Disease
Lead Sponsor:
Swiss Federal Institute of Technology
Collaborating Sponsors:
Clinica Hildebrand Brissago
Neurocentro - Istituto di Neuroscienze Cliniche della Svizzera Italiana
Conditions:
Parkinson Disease
Eligibility:
All Genders
35-80 years
Phase:
NA
Brief Summary
It has been shown that patients with Parkinson's disease (PD) have impaired kinaesthesia and haptic perception of the upper limbs. In PD patients, these impairments might be involved in the developmen...
Eligibility Criteria
Inclusion
- Ten patients with Parkinson's disease and 10 age-matched control subjects will be recruited.
- Patients with Parkinson's disease: inclusion criteria
- Diagnosis of idiopathic Parkinson's disease according to UK Parkinson's disease society brain bank clinical diagnostic criteria
- Age between 35 and 80 years
- Hoehn and Yahr stage of I, II or III during the ON state
- Montreal Cognitive Assessment (MoCA) ≥ 26
- No tremor, i.e.:
- Postural tremor for the hand: MDS-UPDRS 3.15 \< 1
- Kinetic tremor of the hands: MDS-UPDRS 3.16 ≤ 1
- Rest tremor amplitude for the extremities: MDS-UPDRS 3.17 \< 1
- Constancy of rest tremor: MDS-UPDRS 3.18 \< 1
- The subject read, understood and signed the informed consent
- Patients with Parkinson's disease: exclusion criteria
- Polyneuropathy registered in the anamnesis or peripheral sensory-motor impairments detected in a neurological clinical examination
- Mild to severe dyskinesia of the upper limbs: point 5 of the Abnormal Involuntary Movement Scale (AIMS) \> 1
- Orthopedic pathologies of the upper limbs or other pathologies possibly interfering with the study
- Pacemaker, deep-brain-stimulator or other active implanted devices
- Control subjects: inclusion criteria
- Age between 35 and 80 years
- Montreal Cognitive Assessment (MoCA) ≥ 26
- The subject read, understood and signed the informed consent
- Control subjects: exclusion criteria
- Any history of neurological, orthopaedic or rheumatologic disease affecting the upper limbs or other pathologies possibly interfering with the study
- Pacemaker or other active implanted devices
Exclusion
Key Trial Info
Start Date :
March 14 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 12 2023
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT05245955
Start Date
March 14 2022
End Date
September 12 2023
Last Update
September 13 2023
Active Locations (1)
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1
Clinica Hildebrand, Centro di Rehabilitazione Brissago
Brissago, Switzerland, 6614