Status:
UNKNOWN
Argon Plasma Coagulation and Clip for the Prophylaxis of Post-polypectomy Bleeding After Hot Snare Polypectomy
Lead Sponsor:
Renmin Hospital of Wuhan University
Conditions:
Post-polypectomy Bleeding
Colorectal Polyp
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Discuss the efficacy and safety of argon plasma coagulation （APC）in comparison with clip closure for preventing colorectal post-procedure bleeding（PPB） after hot snare polypectomy（HSP）; analyze the ri...
Detailed Description
This is a multicenter, randomized and controlled study. It aims to discuss the efficacy and safety of argon plasma coagulation（APC）in comparison with clip closure for preventing colorectal post-proced...
Eligibility Criteria
Inclusion
- age\>18 years
- the diagnosis of colorectal polyps is clear（Paris Ip or Ⅰsp）
- head diameter≥ 10 mm
- HSP indications were met and no contraindications were found
- patients (or the legal representative/guardian) with informed consent
Exclusion
- ASA Grade Ⅲ or above, or end-stage disease of major organs (such as malignancy, heart failure, chronic obstructive pulmonary disease, end-stage renal disease and so on)
- coagulation dysfunction (INR ≥ 1.5, PLT \< 50×10 \^9 / L)
- use antiplatelet drugs within 7 days before the operation, anticoagulant drugs within 5 days, and/or blood products within 30 days after the operation
- there were other lesions in the resection site of the included polyps affecting this study, or the intestinal preparation was insufficient
- incomplete closure of clips (complete closure: spacing between adjacent clips \< 1cm)
- APC is used for polypectomy or intraoperative hemostasis, rather than preventing PPB
- surgical treatment, vascular intervention, or blood products were used during the operation
- use other methods to prevent PPB
- the bleeding site was not confirmed by endoscopy
- history of intestinal surgery
- menstruation or pregnancy
- not following medical advice
- participated in other clinical trials and signed its informed consent
Key Trial Info
Start Date :
March 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 1 2023
Estimated Enrollment :
1017 Patients enrolled
Trial Details
Trial ID
NCT05250518
Start Date
March 1 2022
End Date
October 1 2023
Last Update
February 22 2022
Active Locations (1)
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1
Renmin Hospital of Wuhan University
Wuhan, Hubei, China, 430060