Status:
RECRUITING
Clinical Trial on HIPEC with Mitomycin C in Colon Cancer Peritoneal Metastases (GECOP-MMC)
Lead Sponsor:
Hospital Universitario de Fuenlabrada
Collaborating Sponsors:
Instituto de Investigación Hospital Universitario La Paz
Conditions:
Peritoneal Carcinomatosis
Colon Cancer
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
The aim of this study is to assess whether there are differences in PERITONEAL RECURRENCE in patients with Colon Cancer Peritoneal Metastases treated with complete surgical resection and systemic chem...
Detailed Description
CytoReductive Surgery (CRS) + Hyperthermic IntraPEritoneal Chemotherapy (HIPEC), especially from the year 2000 onwards, has obtained unprecedented results in patients with low to moderate volume perit...
Eligibility Criteria
Inclusion
- Histologically confirmed colon adenocarcinoma, except signet ring cell carcinomas (those with \> 50% of the tumor composed of these cells, which comprise only 1% of all colon adenocarcinomas).
- Absence of previously treated or current extraperitoneal metastases, including distant lymphadenopathy (retroperitoneal, mediastinal, etc), liver metastases, or lung metastases (ruled out by PET-scan in case of doubt).
- Synchronous or metachronous peritoneal metastasis of mild to moderate volume, with a PCI ≤ 20 (Appendix 2) (intraoperative confirmation).
- Macroscopically complete surgical cytoreduction CCS-0 (intraoperative confirmation).
- Treatment with perioperative systemic chemotherapy (SCT), before and/or after surgical procedure.
- Age\> 18 years.
- Acceptable anesthetic/surgical risk: ASA 1-3 (Appendix 3), ECOG 0-1 (Appendix 4). No severe alterations in hematological, renal, cardiac, pulmonary or hepatic function (operable patients).
- Information to the patient and signing of a study-specific informed consent.
Exclusion
- Peritoneal carcinomatosis of any other origin, particularly rectal cancer or appendicular adenocarcinoma, or signet ring cell colon cancer on histology.
- No intraoperative confirmation of peritoneal disease (PCI 0). Likewise, cases of perianastomotic (local) or lymph node (locoregional) recurrences will be excluded.
- High volume peritoneal disease with a PCI\> 20 (intraoperative evaluation).
- Concurrent or previously treated extraperitoneal disease.
- Disease progression during preoperative chemotherapy, if received.
- Patients previously treated with HIPEC.
- History of other cancers (except cutaneous basal cell carcinoma or cervix carcinoma in situ) in the 5 years prior to entry into the study.
- Patients included in another first-line clinical trial for the studied disease.
- Pregnancy (or suspicion of it) or lactation period.
- Emergency surgical intervention for obstruction or perforation of a primary tumour with synchronous PM (although rescue and secondary CRS + HIPEC after emergency surgery of the primary tumour are acceptable if inclusion criteria are fulfilled).
- Persons deprived of liberty or under legal or administrative supervision.
- Inability to understand the nature of the intervention, the risks, benefits, expected evolution and the need to undergo periodic medical examinations, either for geographical, social or psychological reasons.
Key Trial Info
Start Date :
March 2 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 1 2029
Estimated Enrollment :
216 Patients enrolled
Trial Details
Trial ID
NCT05250648
Start Date
March 2 2022
End Date
October 1 2029
Last Update
October 9 2024
Active Locations (31)
Enter a location and click search to find clinical trials sorted by distance.
1
Hospital General Universitario de Elche
Elche, Alicante, Spain, 03203
2
Hospital Universitario Torrecárdenas
Almería, Almería, Spain, 04009
3
Complejo Hospitalario Universitario de Badajoz
Badajoz, Badajoz, Spain, 6080
4
Hospital Sant Joan Despi Moises Broggi
Sant Joan Despí, Barcelona, Spain, 08970