Status:
RECRUITING
The Cardiovascular Impact of Hot Flushes
Lead Sponsor:
University of Minnesota
Conditions:
Hot Flashes
Menopause
Eligibility:
FEMALE
40-70 years
Brief Summary
The overall objective of this study is to examine the physiological responses that occur during a hot flush in postmenopausal women. The following specific aims will be executed to reach the overall o...
Detailed Description
Cardiovascular disease (CVD) increases aggressively after menopause and is the leading cause of mortality in women in the US. Autonomic dysregulation and high blood pressure (BP), often demonstrated i...
Eligibility Criteria
Inclusion
- Postmenopausal (may have or may not have hot flushes)
- Have not started hormone therapy and/or will discontinue hormone therapy for the duration of the study
Exclusion
- Reported nicotine/tobacco use within the last six months
- Diabetic or asthmatic
- Diagnosed significant carotid stenosis
- History of significant autonomic dysfunction, heart disease, respiratory disease, or severe neurologic condition such as stroke or traumatic brain injury
- Existing metabolic or endocrine abnormalities
- Use of heart/blood pressure medications that are determined to interfere with study outcomes
- Unwilling to discontinue use of OC (or other hormonal contraceptives, including intrauterine devices or contraceptive implants) and/or MHT
- Pregnant or breastfeeding
- Unwilling or unable to refrain from consuming caffeine or alcohol in the 12 hours before visit two or three
- Unwilling or unable to refrain from vigorous exercise (at least 10 minutes in duration) in the 12 hours before visit two or three
- Unwilling or unable to fast in the eight hours before visit two or three
- Body mass index greater than or equal to 35 kg/m\^3
Key Trial Info
Start Date :
March 1 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
May 26 2026
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT05251324
Start Date
March 1 2022
End Date
May 26 2026
Last Update
April 15 2025
Active Locations (1)
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1
University of Minnesota
Minneapolis, Minnesota, United States, 55455