Status:
UNKNOWN
Transcranial Alternating Current Stimulation Combined With 40Hz Sound Stimulation for Treatment Alzheimer's Disease
Lead Sponsor:
Chinese PLA General Hospital
Conditions:
Alzheimer Disease
Eligibility:
All Genders
40-80 years
Phase:
NA
Brief Summary
Alzheimer's disease is characterized by progressive cognitive decline, and cognition is associated with cerebral concussion. Previous studies have found reduced gamma energy in the brain of AD patient...
Detailed Description
The number of people with Alzheimer's disease is increasing every year, but the available drugs are not effective. Both transcranial alternating current stimulation (tACS) and sound stimulation are no...
Eligibility Criteria
Inclusion
- Age 40-80 years, male or female;
- Meet the diagnosis AD formulated by the National Institute on Aging and the Alzheimer's Association (NIA-AA) dementia diagnostic criteria;
- Clinical Dementia Rating Scale (CDR) =1.0 or 2.0;
- MMSE score ≤ 24;
- Able to move freely or with the aid of a walker or crutches;
- Good vision and hearing, able to cooperate with examination and treatment;
- Subjects voluntarily joined and had a guardian to sign the informed consent.
Exclusion
- The presence of preoperative structural brain abnormalities (such as tumors, cerebral infarction, hydrocephalus or intracranial hemorrhage);
- The presence of other neurological disorders such as multiple sclerosis, epilepsy, Parkinson's disease, etc;
- Psychiatric system disorders: such as anxiety disorders, affective disorders such as depression, or pharmacogenic psychiatric disorders;
- Severe medical illness, current use of respiratory medications, cardiovascular medications, anticonvulsants or psychoactive drugs and clinically significant gastrointestinal, renal, hepatic, respiratory, infectious, endocrine or cardiovascular disease, cancer, alcoholism or drug addiction;
- Severe hearing and visual impairment;
- Patients with clinical comorbidities with a life expectancy of less than 2 years;
- Patients who have undergone cranial surgery;
- Contraindications to undergoing magnetic resonance imaging or receiving transcranial alternating current stimulation (pacemakers, post DBS surgery);
- Eczema or sensitive skin;
- Familial Alzheimer's disease;
- Presence of other types of dementia: vascular dementia, Lewy body dementia, frontotemporal dementia, infectious dementia, etc;
- Other conditions that, in the opinion of the investigator, may not be suitable for this study.
Key Trial Info
Start Date :
December 23 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 1 2023
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT05251649
Start Date
December 23 2021
End Date
January 1 2023
Last Update
February 23 2022
Active Locations (1)
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1
Chinese PLA General Hospital
Beijing, China, 100853