Status:
ACTIVE_NOT_RECRUITING
Cardiac Imaging in Adults With Congenital Aortic Stenosis
Lead Sponsor:
Erasmus Medical Center
Collaborating Sponsors:
Dutch Heart Foundation
Conditions:
Congenital Aortic Stenosis
Eligibility:
All Genders
18+ years
Brief Summary
The CAS study is a prospective observational cohort study investigating the effects of congenital aortic stenosis (ConAoS) on the left ventricular function and the prevalence, pattern and expanse of l...
Detailed Description
Congenital aortic stenosis (ConAoS) accounts for 4-8% of all congenital cardiac diagnoses. It is often caused by a bicuspid aortic valve (BAV), which has an estimated prevalence of 0.5-2% in the gener...
Eligibility Criteria
Inclusion
- In order to be eligible to participate in this study, a subject must meet the following criteria:
- Aged ≥ 18 years
- Capable of understanding and signing informed consent.
- Inclusion criteria for the CAS study are patients diagnosed with a valvular congenital aortic stenosis. Two groups of patients will be included:
- Patients with a prior aortic valve replacement (AVR)
- Patients without a prior AVR and with an aortic jet velocity ≥ 2.5 m/s.
- Exclusion Criteria:
- Patients with severe aortic regurgitation
- Presence of any of the following contra-indications for MRI
- Contra-indication to gadolinium based contrast media (eGFR \<30 ml/min or contrast allergy)
- Other contra-indications such as presence of pacemaker/implantable cardioverter defibrillator, severe claustrophobia or pregnancy
- Patients known with or previously treated because of aortic coarctation.
- Patients known with genetic syndromes or connective tissue disorders
Exclusion
Key Trial Info
Start Date :
January 13 2022
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 1 2026
Estimated Enrollment :
75 Patients enrolled
Trial Details
Trial ID
NCT05252351
Start Date
January 13 2022
End Date
November 1 2026
Last Update
March 12 2024
Active Locations (1)
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1
Erasmus Medical Center
Rotterdam, South Holland, Netherlands, 3015 GD