Status:
RECRUITING
STrategies for Anticoagulation in Patients With thRombocytopenia and Cancer-associated Thrombosis
Lead Sponsor:
Tzu-Fei Wang
Conditions:
Cancer-associated Thrombosis
Thrombocytopenia
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
Patients with cancer are prone to have blood clots, which are usually treated with blood thinners. The main complication of blood thinners is bleeding. This is especially a concern when the number of ...
Detailed Description
The current proposal is for the pilot trial to assess feasibility of a full-scale RCT. To determine feasibility, the pilot and the full-scale trials will use the same recruitment strategy, inclusion/e...
Eligibility Criteria
Inclusion
- Adult patients (age ≥ 18) with active malignancy (malignancy diagnosed or treated within the previous 6 months, or progressive/relapsed);
- Objectively confirmed VTE within last 14 days for which therapeutic anticoagulation is planned;
- Thrombocytopenia with a platelet count \< 50,000/uL from cancer therapy or malignancy itself;
- Able to provide written informed consent
Exclusion
- Receipt of anticoagulant for index VTE with platelet count \< 50,000/uL for \> 72 hours;
- Superficial vein thrombosis only;
- Life expectancy \< 1 month (as judged by the treating physicians);
- Creatinine clearance \< 30 ml/min;
- Contraindication to LMWH such as a history of heparin induced thrombocytopenia;
- Thrombocytopenia from other causes, such as thrombotic microangiopathy, immune thrombocytopenia, disseminated intravascular coagulation;
- Previously documented history of refractoriness to platelet transfusion secondary to HLA antibodies;
- Refusal of blood products;
- Anticoagulation at any dose is deemed unsafe (i.e. active bleeding or bleeding disorders)
Key Trial Info
Start Date :
August 29 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 31 2027
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT05255003
Start Date
August 29 2022
End Date
January 31 2027
Last Update
December 17 2025
Active Locations (4)
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1
University of Alberta
Edmonton, Alberta, Canada
2
The Ottawa Hospital
Ottawa, Ontario, Canada, K1H 8L6
3
Niagara Health - St. Catharines Site
Saint Catharines, Ontario, Canada
4
Windsor Regional Hospital
Windsor, Ontario, Canada, N8W 1L9