Status:
UNKNOWN
Machine-learning Algorithm to Differentiate Intraoperative Ketamine Dosing Based on Electroencephalographic Density Spectrum Array Analysis
Lead Sponsor:
Taipei Veterans General Hospital, Taiwan
Conditions:
Electroencephalographic Density Spectrum Array Analysis
Density Spectrum Array
Eligibility:
All Genders
20-80 years
Brief Summary
Ketamine is widely used in the setting of multimodal general anesthesia, and the Electroencephalographic density spectral array (DSA) monitoring has been implemented in the practice of anesthesia. The...
Detailed Description
In this single-blinded randomized controlled trial, we enroll 90 patients undergoing major spine surgery, and candidates are divided into 3 groups: A (control group using sevoflurane only), B (sevoflu...
Eligibility Criteria
Inclusion
- Patients undergoing elective spine surgery
- Aged 20-80 years old
Exclusion
- Pregnancy
- Presence of major brain disorders: stroke, epilepsy, Parkinson's disease, etc.
- Any of the following major organ disorders:
- Chronic pulmonary disease (Clinically diagnosed severe chronic obstructive pulmonary disease or FEV1/FVC \<70% or FEV1 \<50%)
- Heart failure (NYHA III or IV)
- Chronic renal failure (eGFR\<60ml/min/1.73m2)
- Ongoing sepsis or infection
- Ongoing of history of CNS-acting medications/substances use (e.g.: sedatives, hypnotics, stimulants, etc.)
Key Trial Info
Start Date :
March 1 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2022
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT05256264
Start Date
March 1 2022
End Date
December 31 2022
Last Update
August 17 2022
Active Locations (1)
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1
Taipei Veterans General Hospital
Taipei, Beitou, Taiwan, 112