Status:
COMPLETED
Impact of Chest Wall Mechanics on Lung and Cardiovascular Function During Delayed Sternal Closure
Lead Sponsor:
The Hospital for Sick Children
Collaborating Sponsors:
Children's Hospital Los Angeles
Conditions:
Palliation of Congenital Heart Diseases
Cardiopulmonary Bypass
Eligibility:
All Genders
Up to 28 years
Phase:
NA
Brief Summary
This study aims to describe chest wall mechanics during delayed sternal closure (DSC) in neonates following cardiopulmonary bypass or palliation of congenital heart diseases.
Detailed Description
This research study is being done so that investigators can understand the complex interactions between the heart, the lungs and the chest wall after heart surgery. Understanding this may guide future...
Eligibility Criteria
Inclusion
- Informed consent provided by parent or primary guardian.
- Aged \<28 days of life at the time of cardiac surgery.
- Undergone surgery using CPB for congenital heart disease.
- Undergoing DSC in CCCU.
Exclusion
- Gestational age \< 37 weeks or weight \< 2 kg at the time of surgery.
- Endotracheal tube leak \>20%.
- Need of extracorporeal support (ECMO), inhaled nitric oxide.
- Pre-existing pulmonary disease (For example: Congenital diaphragmatic hernia).
- Pre-existing or new arrhythmia that can impact hemodynamic assessment.
- Severe coagulopathy or any other contraindication for the insertion of a nasogastric catheter (e.g., history of tracheo-esophageal fistula).
Key Trial Info
Start Date :
August 26 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 8 2024
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT05257525
Start Date
August 26 2022
End Date
January 8 2024
Last Update
July 16 2025
Active Locations (1)
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1
The Hospital for Sick Children
Toronto, Ontario, Canada