Status:
ENROLLING_BY_INVITATION
Stereotactic Arrhythmia Radioablation for Ventricular Tachycardia (StAR-VT)
Lead Sponsor:
McGill University Health Centre/Research Institute of the McGill University Health Centre
Conditions:
Ventricular Tachycardia
Arrhythmia
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
In 2017 a novel treatment approach to a series of 5 patients with refractory VT was introduced, using ablative radiation with a stereotactic body radiation therapy (SBRT) technique to arrhythmogenic s...
Detailed Description
Ventricular tachycardia (VT) is a potentially life-threatening arrhythmia characterized by electrical re-entry within patches of heterogeneous myocardial fibrosis leading to sustained consecutive vent...
Eligibility Criteria
Inclusion
- 18 years of age
- Ishemic or non-ischemic cardiomyopathy
- Recurrent episodes of monomorphic ventricular tachycardia having failed standard treatment with at least 1 antiarrhythmic drug
- Previous endocardial and/or epicardial electrophysiology study and ablation.
- Participants who have a contraindication to electrophysiology studies (ventricular thrombus, absence of vascular access, valvular heart disease or mechanical heart valve that precludes left-ventricular access) may be eligible for the protocol provided the arrhythmic substrate can be defined through non-invasive methods.
Exclusion
- Previous RT in the treatment field that precludes furth RT
- Active connective tissue disease
- Interstitial pulmonary fibrosis
- Pregnant or breastfeeding individuals
- Participants who plan to become pregnant or breast feed during the study duration
Key Trial Info
Start Date :
July 1 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2031
Estimated Enrollment :
9 Patients enrolled
Trial Details
Trial ID
NCT05258422
Start Date
July 1 2023
End Date
December 31 2031
Last Update
March 18 2025
Active Locations (1)
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1
Cedars Cancer Center, McGill University Health Centre
Montreal, Quebec, Canada, H4A3J1