Status:
COMPLETED
Investigating the Anabolic Response to Resistance Exercise After Critical Illness (ARTIST-2)
Lead Sponsor:
Karolinska University Hospital
Conditions:
Critical Illness
Muscle Loss
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
ICU survivors often suffer from long-term functional disability. An attenuated response to physical exercise in skeletal muscle after critical illness may contribute to persisting weakness. The aim o...
Detailed Description
Background The debilitating impact of critical illness has been recognized for several decades. Disability related to intensive care is now described as a syndrome called ICU-acquired weakness (ICUAW...
Eligibility Criteria
Inclusion
- Adult (≥18 years) previously admitted to an ICU at Karolinska University Hospital for ≥3 days and discharged alive from hospital
- OR
- Adult (≥18 years) without a history of ICU admission (control group)
Exclusion
- Not able to provide informed consent
- \>6 months since ICU discharge\*
- Warfarin or dual antiplatelet therapy
- Clinically significant inherited or acquired disorder of hemostasis
- Lower-limb amputee
- Lower-limb atherosclerotic disease with critical ischemia.
- Recent fracture in lower limbs or significant osteoarthritis limiting movement in knee or hip joint
- Metastatic cancer or active hematological malignancy
- Inherited disorder of amino acid metabolism.
- Chronic muscle, neuromuscular or neurologic disease with prior documentation of clinically significant lower-limb involvement
- Pregnancy
- Single organ failure not requiring invasive mechanical ventilation during ICU stay\*
- Intubated only for airway protection with no other organ failure(s) during ICU stay\*
- Planned postoperative care in ICU after elective cardiothoracic surgery\*
- Exclusion criteria marked with asterisk only apply to former ICU patients.
Key Trial Info
Start Date :
March 8 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 18 2024
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT05261984
Start Date
March 8 2022
End Date
January 18 2024
Last Update
February 20 2024
Active Locations (1)
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1
Karolinska University Hospital
Huddinge, Stockholm County, Sweden, 14186