Status:
COMPLETED
Study to Evaluate the Use of Direct Oral Anticoagulants in UK Clinical Practice For Patients With a First Stroke Attributable to Nonvalvular Atrial Fibrillation
Lead Sponsor:
Daiichi Sankyo UK Ltd, a Daiichi Sankyo Company
Conditions:
Atrial Fibrillation
Eligibility:
All Genders
18+ years
Brief Summary
National Institute of Health and Care Excellence (NICE) guidance recommends anticoagulation for stroke prevention in high risk patients with nonvalvular atrial fibrillation (AF). Early evidence sugge...
Detailed Description
This non-interventional study will focus specifically on the patient characteristics, management pathways, and patient reported experiences associated with real world use of three direct anti-FXa oral...
Eligibility Criteria
Inclusion
- \- For all patients:
- Participants presenting to the study centre with a first ischaemic stroke which is, in the clinician's opinion, attributable to nonvalvular AF
- Participants aged 18 years or over at time of first stroke
- For group 2 patients:
- \* Participants initiated on apixaban, edoxaban or rivaroxaban after their first stroke
Exclusion
- For all patients:
- Participants prescribed any anticoagulant for any purpose in the 12 months prior to stroke diagnosis
- Participants with haemorrhagic stroke
- Participants with diagnosis of transient ischemic attack
- Participants with severe cognitive or emotive deficit
- Participants whose medical records are not available for review
- Participant unwilling or unable to give written informed consent
- For group 2 patients:
- Participant unwilling or unable to complete the patient-reported questionnaires
Key Trial Info
Start Date :
February 15 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 9 2021
Estimated Enrollment :
234 Patients enrolled
Trial Details
Trial ID
NCT05262322
Start Date
February 15 2019
End Date
July 9 2021
Last Update
July 19 2022
Active Locations (8)
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1
Queen Elizabeth University Hospital - NHS Greater Glasgow and Clyde
Glasgow, United Kingdom, G51 4TF
2
Gloucestershire Royal Hospital - Gloucestershire Hospitals NHS Foundation Trust
Gloucester, United Kingdom, GL1 3NN
3
Leicester Royal Infirmary - University Hospitals of Leicester NHS Trust
Leicester, United Kingdom, LE1 5WW
4
St George's Hospital - St George's University Hospital's NHS Foundation Trust
London, United Kingdom, SW17 0QT