Status:
COMPLETED
Maximal Exercise Capacity at 2500 m of High Altitude
Lead Sponsor:
University of Zurich
Conditions:
High Altitude Pulmonary Hypertension
Maximal Exercise Capacity
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The impact of hypoxia on maximal work rate during incremental ramp exercise within 3-6 hours after arriving at 2500m of high altitude in patients with precapillary pulmonary hypertension
Eligibility Criteria
Inclusion
- Informed consent as documented by signature (Appendix Informed Consent Form)
- PH class I (PAH) or IV (CTEPH) diagnosed according to guidelines: mean pulmonary artery pressure \>20 mmHg, pulmonary vascular resistance ≥3 wood units, pulmonary arterial wedge pressure ≤15 mmHg during baseline measures at the diagnostic right-heart catheterization
Exclusion
- resting partial pressure of oxygen \<8 kilopascal at Zurich at 490 m low altitude
- exposure to an altitude \>1000 m for ≥3 nights during the last 2 weeks before the study
- inability to follow the procedures of the study
- other clinically significant concomitant end-stage disease (e.g., renal failure, hepatic dysfunction)
Key Trial Info
Start Date :
October 20 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 15 2022
Estimated Enrollment :
28 Patients enrolled
Trial Details
Trial ID
NCT05264324
Start Date
October 20 2021
End Date
April 15 2022
Last Update
May 11 2022
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Respiratory Clinic, University Hospital of Zurich
Zurich, Switzerland, 8091