Status:
RECRUITING
Assessment of Endothelial Glycocalyx in Patients With Primary Open-angle Glaucoma
Lead Sponsor:
Fondation Ophtalmologique Adolphe de Rothschild
Conditions:
Primary Open-angle Glaucoma
Glaucoma
Eligibility:
All Genders
18+ years
Brief Summary
The glycocalyx is a fibrillary lining structure that covers the inner surface of blood vessels. Composed of glycoproteins and polysaccharides, it is an essential determinant of vascular endothelial ph...
Detailed Description
This study propose to extend the exploration of the ischemic theory of glaucoma by a specific imaging technique (the GlycoCheck) which allows an assessment of the microvascular system integrity by giv...
Eligibility Criteria
Inclusion
- Express consent to participate in the study
- Only for case group: primary open angle glaucoma (defined as the presence of visual field damage attributed to glaucomatous optic neuropathy) in both eyes
- Only for control group: Absence optic nerve pathology (including primary open angle glaucoma)
Exclusion
- Pregnant or breastfeeding woman
- Sleep apnea
- Renal insufficiency
- Parkinson's disease
- Alzheimer's disease
- Antiphospholipid syndrome
- Cancer for which treatment ended less than 2 years ago
- Stroke less than 1 year ago
- Myocardial infarction less than 1 year ago
Key Trial Info
Start Date :
May 6 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
May 1 2026
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT05264818
Start Date
May 6 2022
End Date
May 1 2026
Last Update
December 8 2025
Active Locations (1)
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1
Hôpital Fondation A. de Rothschild
Paris, France, 75019