Status:
COMPLETED
ATP Level and Cough Sensitivity to ATP in Subjects With Refractory/Unexplained Chronic Cough
Lead Sponsor:
Kefang Lai
Conditions:
Refractory/Unexplained Chronic Cough
Eligibility:
All Genders
18+ years
Brief Summary
This is a cross-sectional study to investigate ATP level in induced sputum and cough sensitivity to ATP in subjects with refractory/unexplained chronic cough. 60 patients with refractory/unexplained c...
Eligibility Criteria
Inclusion
- Inclusion criteria for patients:
- ≥18 years old
- cough as sole symptom lasting ≥6 months
- cough visual analogue score ≥30mm
- diagnosed as RCC/UCC according to guidelines
- Exclusion criteria for patients:
- smoking currently or in the past 6 months, or a smoking history of \>20 pack-year
- a forced expiratory volume in 1 second/forced vital capacity ratio \<70%;
- use of inhaled/oral corticosteroid, bronchodilators, anti-allergic medicine, antitussive medicine or anti-reflux treatment in the past 1 week;
- a history of acute respiratory infection in the past 4 weeks;
- a history of severe disease (cancer, acute coronary syndrome and so on).
- Healthy control aged ≥18 years old are included. Exclusion criteria are as follow:
- smoking currently or in the past 6 months, or a smoking history of \>20 pack-year
- a forced expiratory volume in 1 second/forced vital capacity ratio \<70%
- a history of acute respiratory infection in the past 4 weeks
- posstive findings of chest radiography
- a history of chronic respiratory disease and allergic disease
- any signs of cough hypersensitivity
Exclusion
Key Trial Info
Start Date :
May 16 2022
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 24 2024
Estimated Enrollment :
131 Patients enrolled
Trial Details
Trial ID
NCT05265871
Start Date
May 16 2022
End Date
January 24 2024
Last Update
May 11 2025
Active Locations (1)
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1
Guangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, The First Affiliated Hospital of Guangzhou Medical University
Guangzhou, Guangdong, China