Status:
UNKNOWN
Effects of Ciprofol Anesthesia on Learning and Memory Function and Antidepressant Effects of ECT in Depressive Patients
Lead Sponsor:
First Affiliated Hospital of Chongqing Medical University
Conditions:
Depressive Disorder
Eligibility:
All Genders
16-45 years
Phase:
EARLY_PHASE1
Brief Summary
In this clinical study, propofol was used as the positive control, and a randomized controlled trial design was used to observe the effects of ciprofol anesthesia on learning and memory function and a...
Detailed Description
Ciprofol injection, whose active component (HSK3486) is propofol analogue, is a novel treatment for anesthesia induction and maintenance. It has been authorized for commercialization in China on Decem...
Eligibility Criteria
Inclusion
- Depressed patients who plan to receive MECT.
- Meet the diagnostic criteria of DSM-IV depression
- 16≤age≤45 years old, gender is not limited
- ASA score is I or II
- The depressive episode lasted for at least 2 weeks
- Clearly understand and voluntarily participate in the study and sign the informed consent form.
Exclusion
- Combined with serious physical diseases, such as uncontrolled hypertension, coronary heart disease, intracranial vascular malformations, asthma attacks, severe liver and kidney dysfunction, etc.
- Foreign bodies in the body: such as pacemakers, intracranial electrodes, etc.
- Those who have a history of epilepsy
- Those who are taking reserpine
- Those with acute and systemic infectious diseases, with moderate or higher fever
- Those with a history of manic episodes
- Those with anesthetics, Allergic to muscle relaxants
- Pregnant women
- Glaucoma
- Bipolar disorder, or combined with other mental illnesses, mental retardation
- Those who are judged not suitable for MECT treatment by the competent physician
- History of drug abuse
Key Trial Info
Start Date :
March 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2024
Estimated Enrollment :
390 Patients enrolled
Trial Details
Trial ID
NCT05266560
Start Date
March 1 2022
End Date
December 31 2024
Last Update
March 4 2022
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