Status:
ACTIVE_NOT_RECRUITING
Ketamine and Kidney Injury in Cardiac Surgery
Lead Sponsor:
Mayo Clinic
Conditions:
Cardiac Surgery
Eligibility:
All Genders
70+ years
Phase:
PHASE4
Brief Summary
The purpose of this study is to investigate the affects of ketamine use for anesthesia at the beginning of heart surgery on kidneys compared to the use of propofol.
Eligibility Criteria
Inclusion
- Presenting for cardiac surgery at the Mayo Clinic in Rochester, Minnesota.
- Scheduled to undergo complex cardiac surgery with the use of cardiopulmonary bypass. Complex cardiac surgery will be defined as surgery involving more than one heart valve, redo-sternotomy procedures, or combined valvular and coronary artery bypass graft procedures (aortic repair not excluded if meets other criteria).
Exclusion
- Left or right ventricular assist device implantation or explantation.
- Procedures not requiring cardiopulmonary bypass.
- Active infection or sepsis requiring antimicrobial therapy and/or vasopressor therapy (treated endocarditis is not excluded).
- Severe hepatic disease resulting in ascites.
- Pre-operative significant renal dysfunction including a baseline creatinine equal to or greater than 2 mg/dL or requiring dialysis.
- Immunosuppressive medication use (including current IV or oral steroids use, use of anti-rejection medications for transplant within 1 month, or chemotherapy within 6 months).
- Immunodeficiency syndrome including HIV/AIDS, leukemia, and multiple myeloma
Key Trial Info
Start Date :
March 2 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2026
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT05268562
Start Date
March 2 2022
End Date
June 1 2026
Last Update
October 7 2025
Active Locations (1)
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1
Mayo Clinic in Rochester
Rochester, Minnesota, United States, 55905