Status:
UNKNOWN
Au-Ag-Cu2O NG With PTT Anti Drug-resistant Microbial Keratitis
Lead Sponsor:
Second Affiliated Hospital, School of Medicine, Zhejiang University
Conditions:
Keratitis, Ulcerative
Antibiotic Resistance, Microbial
Eligibility:
All Genders
18-80 years
Phase:
EARLY_PHASE1
Brief Summary
This clinical study was conducted to evaluate the efficacy and safety of gold-silver cuprous oxide composite nanogels combined with photothermal therapy system in the treatment of severe drug-resistan...
Eligibility Criteria
Inclusion
- The monocular cases of severe infectious keratitis admitted to our center were diagnosed as fungal keratitis according to their medical history, physical signs and surface secretions smear examination of corneal ulcer lesions (severe was defined as subjects with visual acuity \< 0.15, deep stromal infiltration or involvement diameter \>2mm, with extensive infiltration around or with extensive suppuration)
- After more than 2 weeks of active treatment with antibiotics, there was no effect
- The researchers communicated with the subjects in detail, and the subjects cooperated well and they voluntarily participated and signed informed consent
Exclusion
- Allergic to the drug in this test.
- Pregnant and lactating women.
- The medical history suggests serious heart, lung, liver, kidney dysfunction.
- Patients with other factors that would affect the results of this result.
- No signed informed consent.
Key Trial Info
Start Date :
August 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 1 2024
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT05268718
Start Date
August 1 2021
End Date
July 1 2024
Last Update
March 7 2022
Active Locations (1)
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1
Second Affiliated Hospital of Zhejiang University School of Medicine
Hangzhou, Zhejiang, China, 310009