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Status:

RECRUITING

International Leukemia Target Board

Lead Sponsor:

Princess Maxima Center for Pediatric Oncology

Conditions:

Relapsed Hematologic Malignancy

Refractory Hematologic Malignancy

Eligibility:

All Genders

Up to 25 years

Brief Summary

The iLTB is a proof-of-concept initiative for children with r/r hematological malignancies, in which available treatment options will be prioritized by actionable events in a harmonized and uniform se...

Detailed Description

Improvements in outcome for pediatric hematological malignancies have mainly been driven by the optimization of multi-agent chemotherapy regimens, minimal residual disease monitoring, and risk group s...

Eligibility Criteria

Inclusion

  • Inclusion criteria
  • The patient has been diagnosed with a R/R hematological malignancy;
  • The patient is less than 18 years of age at the time of first diagnosis and less than 25 years at the time of inclusion with relapse/refractory hematological malignancy;
  • The patient is treated in a pediatric/AYA setting or study protocol, with no current standard of care treatment;
  • The patients' life expectancy is at least 6 weeks;
  • The patient has undergone any sort of molecular profiling of his/her tumor and the re-sults of this analysis are available;
  • The patient has undergone flow cytometry in a certified lab and results are available;
  • Written informed consent of patient and/or parent(s)/guardian(s) to discuss the patient in the iLTB according to local law and legislation has been obtained.
  • Exclusion criteria: none defined

Exclusion

    Key Trial Info

    Start Date :

    December 31 2022

    Trial Type :

    OBSERVATIONAL

    Allocation :

    ESTIMATED

    End Date :

    June 1 2032

    Estimated Enrollment :

    600 Patients enrolled

    Trial Details

    Trial ID

    NCT05270096

    Start Date

    December 31 2022

    End Date

    June 1 2032

    Last Update

    January 9 2026

    Active Locations (7)

    Enter a location and click search to find clinical trials sorted by distance.

    Page 1 of 2 (7 locations)

    1

    UH Gent

    Ghent, Belgium

    2

    Righospitalet

    Copenhagen, Denmark

    3

    Semmelweis

    Budapest, Hungary

    4

    Princess Máxima Center for Pediatric Oncology

    Utrecht, Utrecht, Netherlands, 3584CS