Status:
UNKNOWN
Oral Minoxidil for the Treatment of Recurrent Platinum Resistant Epithelial Ovarian Cancer
Lead Sponsor:
Loyola University
Collaborating Sponsors:
Cures Within Reach
Medical University of South Carolina
Conditions:
Ovarian Cancer
Eligibility:
FEMALE
18-90 years
Phase:
PHASE2
Brief Summary
The primary purpose of this study is to determine the response rate of patients with recurrent platinum resistant ovarian cancer when treated with oral minoxidil. Secondary objectives include estimati...
Detailed Description
Minoxidil is approved by the Food and Drug Administration (FDA) for treatment of hypertension. In previous studies, the sulfonylurea receptor (SUR) subunit controls the selectivity of the pharmacologi...
Eligibility Criteria
Inclusion
- Inclusion Criteria
- Participants must have recurrent platinum resistant ovarian cancer. Histologic documentation of the recurrence is not required.
- Participants must have platinum resistant disease defined as recurrence less than 6 months after initial platinum based treatment.
- Participants must be greater than or equal to 18 years of age.
- Participants must have an Eastern Cooperative Group (ECOG) Performance Status (PS) less than or equal to 2.
- Participants must be able to take oral medications.
- Exclusion Criteria
- Participants must not have had chemotherapy or radiotherapy within 4 weeks
- Participants must not be receiving any other investigational agents.
- Participants must not have brain metastases
- Participants must not have allergic reactions to minoxidil
- Participants must not have congestive heart failure
- Participants must not have history of cardiac disease
- Participants must not have uncontrolled hypertension
- Participants must not be on dialysis
Exclusion
Key Trial Info
Start Date :
December 13 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2024
Estimated Enrollment :
34 Patients enrolled
Trial Details
Trial ID
NCT05272462
Start Date
December 13 2021
End Date
December 31 2024
Last Update
October 5 2023
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Loyola University Medical Center
Maywood, Illinois, United States, 60153