Status:
RECRUITING
Stimulation of the Larynx to Treat Unexplained Chronic Cough
Lead Sponsor:
University of Minnesota
Conditions:
Cough
Eligibility:
All Genders
18-88 years
Phase:
NA
Brief Summary
Researchers will test the effect of non-invasive vibrotactile stimulation of the larynx on symptom severity of unexplained chronic cough.
Eligibility Criteria
Inclusion
- Adults aged 18-88
- \>8 weeks of cough
- Cough visual analogue scale (VAS): Rating of 30 or greater on a 0-100 cough severity scale
- Ability to provide informed consent and independently complete questionnaires
- Ability to read and speak English
Exclusion
- Electronic implants (e.g., pacemaker)
- Currently doing speech therapy for cough
- Contraindications to safe or effective VTS device use
- No regular access to wifi internet Neuromuscular impairment that may affect cough/laryngeal sensation and/or function (e.g., multiple system atrophy, Parkinson, CVA, vocal fold paralysis or paresis)
- Untreated carotid disease
- BMI \> 40 (for transmission of VTS through soft tissue)
- Current or recent (quit \< 3 months ago) smoking
- Known currently infectious cause for cough (e.g., TB, pertussis, COVID)
- History of known or suspected aspiration pneumonia
- Diagnosis or clinical suspicion of chronic obstructive pulmonary disease (COPD)
- Diagnosis or clinical suspicion of interstitial lung disease (ILD)
- Unmanaged reflux
- Unmanaged allergies/postnasal drip
Key Trial Info
Start Date :
July 13 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 30 2027
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT05273190
Start Date
July 13 2021
End Date
December 30 2027
Last Update
August 11 2025
Active Locations (1)
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1
University of Minnesota
Minneapolis, Minnesota, United States, 55455