Status:
COMPLETED
Effect of Neoadjuvant Anti-PD-1 Immunotherapy on Perioperative Analgesia and Postoperative Delirium
Lead Sponsor:
Tianjin Medical University Cancer Institute and Hospital
Collaborating Sponsors:
Tianjin Medical University General Hospital
Tianjin Chest Hospital
Conditions:
Immunotherapy
Analgesia
Eligibility:
All Genders
18+ years
Brief Summary
To observe the effect of preoperative anti-PD-1 monotherapy combined with chemotherapy on patients' perioperative pain and opioid analgesia, and evaluate its effect on the incidence and severity of pa...
Detailed Description
In this study, the investigators intend to select patients with resectable NSCLC treated with immuno-neoadjuvant therapy in combination with chemotherapy, systematically observe the effect of preopera...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Histologically confirmed stage II or stage IIIA non-small cell lung cancer (NSCLC) and meet the requirements for R0 resection;
- American Society of Anesthesiologists (ASA): I-III, age ≥18 years, body mass index (BMI): 18.5-30;
- Normal function of Coagulation and vital organs such as heart, lungs, kidney, and liver;
- Eligible to receive platinum-containing two-drug chemotherapy;
- Sign the informed consent form
- Exclusion Criteria
- Prior treatment of any kind for current lung cancer, including chemotherapy, radiation or targeted therapy;
- Preoperative opioid analgesia;
- Severe chronic or active infection requiring systemic antibacterial, antifungal or antiviral therapy, including tuberculosis infection;
- History of antipsychotic medication in the last 6 months;
- Preoperative Mini-mental state examination (MMSE) score \<23
Exclusion
Key Trial Info
Start Date :
March 22 2022
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 2 2024
Estimated Enrollment :
81 Patients enrolled
Trial Details
Trial ID
NCT05273827
Start Date
March 22 2022
End Date
January 2 2024
Last Update
January 5 2024
Active Locations (3)
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1
Tianjin Medical University Cancer Institute and Hospital
Tianjin, Tianjin Municipality, China, 300060
2
Tianjin Chest Hospital
Tianjin, China
3
Tianjin Medical University General Hospital
Tianjin, China