Status:
UNKNOWN
Effect of Intraoperative Dexmedetomidine on Postoperative Delirium in Elderly Patients Undergoing Robot-assisted Pancreaticoduodenectomy: a Randomized Controlled Study
Lead Sponsor:
Chinese PLA General Hospital
Collaborating Sponsors:
Beijing Tiantan Hospital
Conditions:
Delirium in Old Age
Eligibility:
All Genders
65+ years
Phase:
NA
Brief Summary
To observe the effect of intraoperative dexmedetomidine on the incidence of postoperative delirium, postoperative analgesic drug requirements and pain scores in elderly patients undergoing robot-assis...
Detailed Description
This study is a multicenter, randomized, double-blind, placebo-controlled trial. Three hundred patients undergoing elective robotic-assisted pancreaticoduodenectomy were randomized to the intervention...
Eligibility Criteria
Inclusion
- Patients over 65 years old
- Patients undergoing elective robotic-assisted pancreaticoduodenectomy.
- Written informed consent was obtained.
Exclusion
- Patients with severe preoperative cognitive impairment (MMSE ≤ 20) who are unable to undergo a follow-up evaluation.
- Patients with history of psychiatric or neurological disorders.
- Patients with body mass index ≤ 18 or ≥ 30
- Pregnant or lactating women
- Patients with severe bradycardia (heart rate less than 40 beats per minute)
- Patients with pathological sinus node syndrome or grade 2 or greater AV block
- Patients with severe hepatic or renal insufficiency.
- Patients with severe hypertension (systolic blood pressure ≥ 180 mmHg or diastolic blood pressure ≥ 110 mmHg)
Key Trial Info
Start Date :
April 15 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
April 1 2024
Estimated Enrollment :
300 Patients enrolled
Trial Details
Trial ID
NCT05274789
Start Date
April 15 2022
End Date
April 1 2024
Last Update
June 30 2022
Active Locations (1)
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1
Beijing Tiantan Hospital,Capital Medical University
Beijing, China