Status:
RECRUITING
Effect of an Intervention to Prevent Acute Kidney Injury Versus Standard Care in High-risk Patients After Major Surgery
Lead Sponsor:
University Hospital Muenster
Collaborating Sponsors:
Baxter Healthcare Corporation
Conditions:
Acute Kidney Injury (Nontraumatic)
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
There is no specific therapy for acute kidney injury. It is presumed that supportive measures improve the care and outcome of patients with acute kidney injury. To investigate whether an implementati...
Detailed Description
All patients will receive standard of care therapy according to the standards of our center. After identifying surgical patients with a moderate or severe (stage 2 or 3) AKI patients will be randomly ...
Eligibility Criteria
Inclusion
- Adult patients (age ≥18 years)
- Moderate or severe AKI ((defined by the 2012 KDIGO criteria, KDIGO stage 2 and 3), determined by either serum creatinine or urine output) within 72h after a surgical procedure
- Written informed consent
Exclusion
- Dialysis-dependent chronic kidney disease
- Prior kidney transplant
- Infections with human immunodeficiency virus or hepatitis
- Hepatorenal syndrome
- Pregnancy or breast-feeding
- Participation in another interventional trial that investigates a drug that affects the kidney function within the last 3 months
- Persons held in an institution by legal or official order
- Persons with any kind of dependency on the investigator or employed by the responsible institution or investigator
Key Trial Info
Start Date :
March 22 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2025
Estimated Enrollment :
480 Patients enrolled
Trial Details
Trial ID
NCT05275218
Start Date
March 22 2023
End Date
December 1 2025
Last Update
August 1 2024
Active Locations (1)
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1
University Hospital Münster; 1Department of Anesthesiology, Intensive Care Medicine and Pain Medicine
Münster, Germany