Status:
COMPLETED
Mechanisms of Human Heat Perception - Involvement of TRPA1, TRPV1 and TRPM3
Lead Sponsor:
Medical University of Vienna
Conditions:
Pain
Eligibility:
All Genders
18-70 years
Phase:
EARLY_PHASE1
Brief Summary
Animal studies suggest that the ion channels TRPV1, TRPA1 and TRPM3 are the relevant heat sensors. This study aims to validate these findings in humans.
Detailed Description
Surprisingly, it is still not fully understood how humans perceive heat pain. There are several heat-sensitive ion channels whose manipulation in animals resulted in a more or less pronounced phenotyp...
Eligibility Criteria
Inclusion
- Age between 18 and 70 years
- Full legal capacity
- To ensure an equal number of each sex in the study population, only volunteers of one sex will be included as soon as the number of subjects with the other sex has reached half of the calculated sample size.
Exclusion
- Participant of another study, ongoing or within the last 4 weeks
- Medication intake (except contraception) or drug abuse
- Female subjects: Positive pregnancy test or breastfeeding
- Body temperature above 38°C, diagnostically verified
- Known allergic diseases, in particular asthmatic disorders and skin diseases, known allergic reactions to citrus fruits (but excluding food intolerances).
- Sensory deficit, skin disease or hematoma of unknown origin in physical examination of the test site
- Symptoms of a respiratory tract infection (Covid-19 related criterion)
Key Trial Info
Start Date :
June 13 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 30 2022
Estimated Enrollment :
51 Patients enrolled
Trial Details
Trial ID
NCT05275751
Start Date
June 13 2022
End Date
November 30 2022
Last Update
March 17 2023
Active Locations (1)
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1
Medical University of Vienna
Vienna, Austria, 1090