Status:
UNKNOWN
Role of Photic and Non-photic Time Cues in Resetting Circadian Rhythms
Lead Sponsor:
Brigham and Women's Hospital
Conditions:
Light Exposure
Meal Timing
Eligibility:
All Genders
18-30 years
Phase:
NA
Brief Summary
The aim of this study is to determine the principal time cue (light or meals) for resetting circadian rhythms in melatonin and metabolic outcomes.
Detailed Description
The objective of this proposal is to construct and compare PRCs describing the relationship between the timing of light exposure and meals across the 24-hour day and the size and direction of shift in...
Eligibility Criteria
Inclusion
- Aged between 18-30 years
- Healthy (no medical, psychiatric or sleep disorders;
- Non-smoking for at least 6 months;
- Body Mass Index of \>18 or \<30 kg/m2;
- Able to maintain 8-hour consistent sleep schedule during the study
- Able to refrain from caffeine, alcohol, medication and supplements during the study
Exclusion
- History of alcohol or substance abuse;
- Positive result on drugs of abuse urine toxicology;
- Current or past history of sleep disorders, including but not limited to obstructive sleep apnea, narcolepsy, insomnia, or any significant sleep complaint
- Psychiatric disorder, or first degree relative with a psychiatric disorder
- Recent acute or chronic medical disorder
- Use of drugs or medication (birth control OK) likely to affect sleep, alertness or light sensitivity, as determined by the investigators
- Visual disorder, including but not limited to color blindness, or family history of glaucoma
- Pregnancy or lactation
- Shift work (past 3 years)
- Transmeridian travel (2 or more time zones) in the past 3 months
- Any other reason as determine by the Principal Investigator
Key Trial Info
Start Date :
July 29 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 30 2025
Estimated Enrollment :
48 Patients enrolled
Trial Details
Trial ID
NCT05276739
Start Date
July 29 2022
End Date
September 30 2025
Last Update
June 7 2023
Active Locations (1)
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1
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02115