Status:
SUSPENDED
Effect of Natural Senolytic Agents & NLRP3 Inhibitors on Osteoarthritis
Lead Sponsor:
Assiut University
Conditions:
Osteoarthritis
Eligibility:
All Genders
40-80 years
Phase:
NA
Brief Summary
Objective: To determine the efficacy of natural senolytic agents and NLRP3 Inflammasome inhibitors for reducing knee symptoms and effusion-synovitis in patients with symptomatic knee osteoarthritis an...
Detailed Description
Osteoarthritis is a progressive degenerative disease of the joint leading to cartilage damage, pain and loss of function affecting an estimated 250 million people worldwide and 27 million people in th...
Eligibility Criteria
Inclusion
- male or female, ages 40-80;
- Are willing to comply with all study related procedures and assessments;
- ambulatory as defined by ability to complete functional performance testing;
- Radiographic evidence of Kellgren-Lawrence grade II-IV osteoarthritis in one or both knees;
- Scores 4-10 on the Numerical Rating Scale (NRS) for pain;
Exclusion
- Pregnant or nursing females.
- Subjects who do not have the capacity to consent themselves.
- Subjects who are unable to tolerate oral medication.
- Subjects with uncontrolled medical conditions .
- Surgery on the Study Knee in the past 6 months.
- intra-articular injection of corticosteroids or hyaluronic acid in the past 6 months.
- subjects with significant liver or renal disease.
Key Trial Info
Start Date :
July 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2024
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT05276895
Start Date
July 1 2022
End Date
December 1 2024
Last Update
July 25 2023
Active Locations (1)
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1
Assiut University, Faculty of Medicine
Asyut, Egypt, 71515