Status:
RECRUITING
INTO-HLH: A Disease Registry for Patients With Hemophagocytic Lymphohistiocytosis (HLH)
Lead Sponsor:
Children's Hospital Medical Center, Cincinnati
Collaborating Sponsors:
Sobi, Inc.
Baylor College of Medicine
Conditions:
Hemophagocytic Lymphohistiocytoses
Eligibility:
All Genders
Brief Summary
The purpose of this observational study is to collect data on the natural history of disease of patients with Hemophagocytic Lymphohistiocytosis (HLH) including diagnosis, treatments, responses, and o...
Detailed Description
Hemophagocytic Lymphohistiocytosis (HLH) is a complex, hyperinflammatory syndrome resulting from the interplay of genetic predisposition and various environmental factors. Despite available treatment ...
Eligibility Criteria
Inclusion
- Patients with clinically suspected or confirmed HLH, including those meeting the HLH-2004 diagnostic criteria (primary or secondary forms, including malignancy) and other forms of HLH (macrophage activation syndrome \[MAS\], cytokine release syndrome \[CRS\], etc.)
- Signed and dated informed consent and assent (adolescents)
Exclusion
- None
Key Trial Info
Start Date :
December 31 2021
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
January 1 2026
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT05277272
Start Date
December 31 2021
End Date
January 1 2026
Last Update
December 18 2025
Active Locations (1)
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1
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, United States, 45229