Status:
RECRUITING
Effect of Thumbtack Needle on Ovarian Function of Women With Diminished Ovarian Reserve (DOR)
Lead Sponsor:
Huazhong University of Science and Technology
Conditions:
Diminished Ovarian Reserve
Eligibility:
FEMALE
18-40 years
Phase:
NA
Brief Summary
Using a multi-center, large sample, randomized, controlled and blind clinical trial to evaluate the effect of thumbtack needle on ovarian function of patients with diminished ovarian reserve (DOR).
Detailed Description
Diminished ovarian reserve (DOR) is the precursor state of ovarian failure, and can cause the decline of women's reproductive function. Some studies have demonstrated that acupuncture can improve ovar...
Eligibility Criteria
Inclusion
- Patients with age between 18 and 40 years;
- Low ovarian reserve: AMH\<1.1ng/ml; or AFC\<7; or 10 U/L\<FSH\<25U/L or FSH/LH\>3.6; or has a history of poor ovarian response, that is, in the last controlled hyperstimulation cycle, the number of retrieved oocytes\<3. Any 2 of the above 4 conditions are met.
- Sign informed consent voluntarily.
Exclusion
- Patient's chromosome is abnormal.
- Patients with previous ovarian surgery because of such as ovarian teratoma or chocolate cyst and so on.
- Patients with uncorrected endocrine disease, such as: Simple hyperthyroidism or hypothyroidism, hyperprolactinemia, insulin resistance, diabetes, adrenal diseases, etc.
- Patients with definitively diagnosed autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, antiphospholipid syndrome, Sjogren's syndrome, Hashimoto's thyroiditis.
- Patients with a history of cancer and has received radiotherapy or chemotherapy.
- Patients had the treatment of acupuncture or thumbtack needle in recent 3 months.
- Patients who take Chinese medicine decoction or granule during the treatment;
- Patients unwilling to sign the informed consent of this study.
Key Trial Info
Start Date :
September 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 31 2026
Estimated Enrollment :
240 Patients enrolled
Trial Details
Trial ID
NCT05277948
Start Date
September 1 2021
End Date
October 31 2026
Last Update
March 14 2022
Active Locations (1)
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1
Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology
Wuhan, Hubei, China, 430030