Status:
COMPLETED
E-cigarettes for Harm Reduction in Adults With Asthma
Lead Sponsor:
Brown University
Collaborating Sponsors:
National Institute of General Medical Sciences (NIGMS)
Conditions:
Smoking
Asthma
Eligibility:
All Genders
21-65 years
Phase:
NA
Brief Summary
Smoking is the main cause of preventable disease and death in the US and impacts respiratory illnesses including COPD and asthma. However, little is known about the effects on smoking and lung health ...
Detailed Description
This study will use an unequally allocated between-subjects (N=30) randomized, controlled design to investigate the influence of complimentary electronic nicotine delivery system (ENDS) provision on c...
Eligibility Criteria
Inclusion
- Male or female (50%), 21 to 65 (inclusive) years of age;
- Persistent asthma symptoms (i.e., episodic symptoms of airflow obstruction / airway hyperresponsiveness (AHR) as documented in review of medical history);
- Currently prescribed SABA medication;
- Past-year smoking of ≥5 cigarettes/day;
- Exhaled CO ≥ 6 ppm at baseline;
- Zero breath alcohol during informed consent for participation;
- English-speaking at an 8th grade level.
Exclusion
- Intention to quit smoking during the next 30 days;
- Current engagement in any smoking cessation treatment;
- Current self-identification as regular ENDS user or using ENDS \> 2 days / week;
- Medical contraindication to nicotine;
- Pregnancy (due to toxicity of nicotine and tobacco products);
- Current alcohol dependence (AUDIT \> 15)
- Urine-screened or past-month self-reported use of illicit substances (amphetamine, cocaine, methamphetamine, opioids, benzodiazepines);
- Current psychosis, mania, or suicidal ideation;
Key Trial Info
Start Date :
May 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 12 2024
Estimated Enrollment :
17 Patients enrolled
Trial Details
Trial ID
NCT05278065
Start Date
May 1 2022
End Date
September 12 2024
Last Update
November 18 2025
Active Locations (1)
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1
Center for Alcohol and Addiction Studies
Providence, Rhode Island, United States, 02903