Status:
COMPLETED
Assessment of Reward Responses to Erythritol Using Flavor Preference Learning
Lead Sponsor:
University Hospital, Basel, Switzerland
Conditions:
Reward Responses
Gastrointestinal Hormones
Eligibility:
All Genders
18-55 years
Phase:
NA
Brief Summary
The aim of this project is to investigate the reward responses to oral erythritol compared to sucrose and sucralose using flavor preference learning in healthy participants. In addition, the release o...
Detailed Description
This trial is a randomized, double-blind, cross-over study; the project set-up will be single-centre, national. The study is composed of six visits: one screening visit, one pre-test visit, three cond...
Eligibility Criteria
Inclusion
- Healthy normal weight participants with a body-mass index (BMI) of 19.0-24.9 kg/m2
- Age 18-55 years
- Stable body weight (±5%) for at least three months
- Able to give informed consent as documented by signature
- 3 drinks rated as neutral and novel (from the flavor preference learning)
Exclusion
- Non-taster (deficits of taste and smell) or supertaster
- Fructose intolerance
- Shift worker
- Pre-existing regular consumption of erythritol and/or sucralose and/or aspartame (\>1/week)
- Substance abuse (more than 1 glass wine/beer per day; consumption of cannabis, cocaine, heroin, etc.)
- Regular intake of medications, except contraceptives
- Chronic or clinically relevant acute infections
- Pregnancy: although no contraindication, pregnancy might influence metabolic state.
- Participation in another study with investigational drug within the 30 days preceding and during the present study
- Pre-existing diet (vegetarian, vegan, sugar free)
- Inability to follow procedures due to psychological disorders or insufficient knowledge of project language (German)
- Calculated dose of erythritol outside the range of 30-60g (per 300mL) (from the sweetness matching)
Key Trial Info
Start Date :
March 17 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 16 2022
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT05279183
Start Date
March 17 2022
End Date
September 16 2022
Last Update
October 12 2022
Active Locations (1)
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1
St. Claraspital
Basel, Switzerland, 4002