Status:
UNKNOWN
Effect Analysis of Neoadjuvant Chemoradiotherapy Combined With Surgery in Laparoscope for Advanced Colon Cancer
Lead Sponsor:
Tang-Du Hospital
Conditions:
Colon Neoplasm
Eligibility:
All Genders
18-70 years
Brief Summary
In this study, a randomized controlled trial was conducted on advanced colon cancer patients with preoperative tumor staging T1-4/N1-2/M0 or T4/N0/M0 to determine the effectiveness of preoperative sho...
Detailed Description
This is prospective,a single-arm, single center, clinical trail study.The patient entered the study after meeting that criteria.The ORR, R0 resection, OS and DFS of patients and neoplasm down-staging ...
Eligibility Criteria
Inclusion
- Diagnosis of colon neoplasm
- 18 years to 70 years
- Preoperative abdominal enhanced CT or MRI showed cT4, cN0-2
- ECOGS score≤2
- thoraco-abdomina CT showed no obvious metastasis（The CT of liver and lung show uncertainty tubercle,suggestive performed PET-CT) cT4,cN0-2,M0 radiography Inclusion Criteria（according postoperative enhanced CT or MRI）
- progress tubercle penetrate peritoneotome base
- progress tubercle penetrate serous surface of neighboring organ
- progress tubercle development by late mesentery or side abdominis
Exclusion
- Appeared other system cancer
- Patient with postoperative recurrent of colon cancer
- Patient with malignancies history in recent 5 years
- Pregnant or female of suckle period
- The patient have adjuvant radiotherapy record in other system cancer before this time treatment，and Patient with surgical contraindications.
- The patient have accepted adjuvant chemoradiotherapy before this time treatment.
- Distant metastasis found during surgery
- Patients with poor radiotherapy compliance and difficulty in coordination
- Patients with mental disorders
Key Trial Info
Start Date :
October 1 2021
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
May 31 2025
Estimated Enrollment :
177 Patients enrolled
Trial Details
Trial ID
NCT05279612
Start Date
October 1 2021
End Date
May 31 2025
Last Update
November 14 2022
Active Locations (1)
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1
General Surgery Gastrointestinal Department,Tang-Du of Fourth Military Medical University
Xi’an, Shanxi, China