Status:
UNKNOWN
PTC in Personalizing Neoadjuvant Therapy for Patients With Advanced Gastrointestinal Tumor
Lead Sponsor:
Peking University
Conditions:
Gastrointestinal Neoplasms
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
To explore the value of PTC drug screening technique in selecting neoadjuvant therapy for advanced gastrointestinal cancer.
Detailed Description
In this study, patients diagnosed with advanced gastrointestinal cancer including locally advanced gastric cancer, locally advanced colorectal cancer and colorectal cancer with liver metastasis. Tumor...
Eligibility Criteria
Inclusion
- diagnosed of gastrointestinal adenocarcinoma by biopsy
- existence of initially resectable lesions evaluated by investigators
- indications of neoadjuvant chemotherapy including: 1) locally advanced gastric cancer cT1-2N1-3M0 \& cT3-4N0-3M0; 2) locally advanced colorectal cancer cT3-4 or N+; 3)colorectal carcinoma with synchronous liver metastases: CRS≤2; 4)other patients who are considered to be appropriate to receive neoadjuvant chemotherapy determined by MDT
- never receive any tumor related treatment including chemotherapy, radiotherapy, and immune therapy
- never diagnosed of other malignancies
- able to tolerate chemotherapy
- ECOG≤2
- life expectance \>6 months
- at least 1 measurable lesions(according to RECIST 1.1)
- informed consent
Exclusion
- pregnant or lactating women
- participating in other clinical trials within 6 months
- MSI-H or dMMR or EBER(+)
- lesion located within 10cm from anal margin
- severe liver dysfunction
- severe renal dysfunction
- cognitive disorder, mental disease or poor compliance
- allergic to known chemotherapeutic agents
- other conditions not suitable to participate in this trial determined by investigators
Key Trial Info
Start Date :
April 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2024
Estimated Enrollment :
420 Patients enrolled
Trial Details
Trial ID
NCT05280210
Start Date
April 1 2022
End Date
December 31 2024
Last Update
March 15 2022
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