Status:
COMPLETED
Effect of Smoking and Periodontal Therapy on Salivary and Gingival Crevicular IL-17 and IL-35
Lead Sponsor:
Gazi University
Conditions:
Periodontitis
Periodontal Diseases
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
Periodontal diseases are among the major causes of tooth loss. Smoking may play a role as a contributing factor in the development of periodontitis by reducing the immune response. The role of cytokin...
Detailed Description
Periodontal diseases are among the complex inflammatory diseases that are considered among the leading causes of tooth loss, mostly observed with multiple etiological factors. The complexity of period...
Eligibility Criteria
Inclusion
- To be volunteer to participate in the study
- To be over 18
- Being systemically healthy
- Having greater than or equal to 15 teeth out of 3rd molar teeth
- To have localized or generalized periodontitis for the experimental group (clinical attachment loss in at least 6 surrounding areas and presence of greater than or equal to 5 mm periodontal pocket)
- For Smoking group; more than 10 cigarettes a day for more than 5 years
- For non-smokers; have not smoked for at least 3 years.
Exclusion
- Have any systemic disease affecting periodontal condition
- To receive periodontal treatment in the last 6 months
- Use any medication that may affect the inflammatory process in the last 3 months
- Use local or systemic antibiotics in the last 3 months
- Pregnancy or lactation for female patients
- Regular use of mouthwash
Key Trial Info
Start Date :
January 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 7 2022
Estimated Enrollment :
55 Patients enrolled
Trial Details
Trial ID
NCT05281848
Start Date
January 1 2018
End Date
March 7 2022
Last Update
March 16 2022
Active Locations (2)
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1
Gazi University Faculty of Dentistry
Ankara, Turkey (Türkiye), 06500
2
Gazi University Faculty of Medicine Immunology Department
Ankara, Turkey (Türkiye), 06560