Status:
ACTIVE_NOT_RECRUITING
Effect of Folic Acid and/or Pentoxifylline on Patients With Chronic Kidney Disease
Lead Sponsor:
Al-Azhar University
Conditions:
Chronic Kidney Diseases
Eligibility:
All Genders
18-60 years
Phase:
PHASE3
Brief Summary
The aim of this study is to evaluate the effect of administration of folic acid and /or pentoxifylline on patients with chronic kidney disease (CKD).
Detailed Description
Chronic kidney disease (CKD) is a worldwide public health problem, with adverse outcomes of kidney failure, cardiovascular disease (CVD), and premature death. Chronic kidney disease (CKD) affects betw...
Eligibility Criteria
Inclusion
- Patients who have chronic kidney disease(CKD) stages 3-5
- Aged between18 - 60 years old.
- Both sexes.
- Stable clinical condition defined as no hospitalizations or cardiovascular events within the 3 months before screening
- Stable renal function (baseline serum creatinine had to have not increased by 50% in the 3 months before screening)
- No changes in concomitant medication during the study.
- Patients who accept to participate in the study.
Exclusion
- Pregnant women
- Current use of PTF
- Contraindication to use of PTF drug: history of PTF or theophylline allergy, history of severe retinal hemorrhage or recent cerebral hemorrhage
- Those with active infections or inflammatory diseases or HIV infection
- Those with chronic liver disease .
- Patients who had received immunosuppressive therapy
- Non-compliant patients
Key Trial Info
Start Date :
January 8 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 19 2026
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT05284656
Start Date
January 8 2022
End Date
December 19 2026
Last Update
June 11 2025
Active Locations (1)
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1
Al Azhar University
Cairo, Egypt