Status:
UNKNOWN
Siderophores for Imaging Infection Using 68Ga-DFO
Lead Sponsor:
Guy's and St Thomas' NHS Foundation Trust
Collaborating Sponsors:
King's College London
Conditions:
Vascular Graft Infection
Eligibility:
All Genders
18+ years
Brief Summary
This is a single center pilot study involving a single study visit for participants, with remote follow up data collected at 24 hours. Follow up at 3 months and 6 months later occurs as standard of ca...
Detailed Description
This study is a first in human mechanistic study hypothesizing that siderophore complexes labelled with a radiotracer (Gallium-68) will be taken up in sites of infection in patients with a vascular gr...
Eligibility Criteria
Inclusion
- Age 18 and older
- Women of childbearing potential must have documented negative pregnancy test prior to tracer administration.
- Willing and able to give informed consent
- Able to comply with the PET imaging protocol
- Patients with vascular grafts in situ
- Positive FDG-PET/CT in the case of patients with suspected or diagnosed graft infections
Exclusion
- Aged under 18
- Pregnancy or lactation
- Prisoners
- Any lack of capacity to consent, including lack of adequate understanding of written or spoken English.
- Iron infusion within 1 week of 68Ga-DFO PET/CT scan (can potentially hamper the sensitivity of DFO by decreasing the number of siderophore receptors in the bacteria).
Key Trial Info
Start Date :
March 15 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
January 31 2024
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT05285072
Start Date
March 15 2022
End Date
January 31 2024
Last Update
March 17 2022
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Kings College London and Guy's and St Thomas' Hospital PET Centre
London, United Kingdom, SE1 7EH