Status:
COMPLETED
Behavioral and Neural Responses to External Alterations of Speech Variability
Lead Sponsor:
University of Wisconsin, Madison
Collaborating Sponsors:
National Institute on Deafness and Other Communication Disorders (NIDCD)
Conditions:
Speech
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The purpose of this research study is to understand how the brain processes and controls speech in healthy people. The investigators are doing this research because it will help identify the mechanism...
Detailed Description
The overall study (Establishing the clinical utility of sensorimotor adaptation for speech rehabilitation) aims to understand how cognitive, perceptual, and motor processes are integrated in the contr...
Eligibility Criteria
Inclusion
- Inclusion Criteria (Patients):
- English-speaking adults
- diagnosed communicative disorder, target populations may include:
- stroke survivors with aphasia
- individuals with cerebellar ataxia
- individuals with parkinson's disease
- individuals who use cochlear implants to hear
- adults who stutter
- Inclusion Criteria (Control):
- English-speaking adults
- normal hearing and speech
- no history of stroke or neurological conditions
- Exclusion Criteria:
- Native language other than English
- Any neurological disorders other than the disorder of interest
- Any history of hearing disorders
- Uncorrected vision problems that prevent participants from seeing visually-presented stimuli
- Significant cognitive impairments that prevent participants from carrying out the task or from giving informed consent
- Vulnerable populations (minors and prisoners)
- Additional exclusionary criteria if participating in neuroimaging:
- Implanted paramagnetic materials (metal clips, plates, pacemakers, etc.)
- Head too large for MEG recording helmet
- Claustrophobia or intolerance of MRI scanner noise
- Low signal to noise ratio in pilot MEG recordings
- High levels of artifacts (eye-blinks, etc.)
- Inability to produce the speech sounds proposed with minimal movement
- Left-handedness
- Additional exclusionary criteria if participating in transcranial magnetic stimulation (TMS):
- Implanted paramagnetic materials (metal clips, plates, pacemakers, etc.)
- Increased risk in the event of a seizure
- Serious heart disease
- Increased intracranial pressure
- Pregnancy
- History of seizures
- Family history of epilepsy
- Epileptogenic medications
- Chronic or transient disruption of sleep (including jet lag)
- History of fainting
- Chronic or transient increase in stressful experiences
- Use of illegal drugs
Exclusion
Key Trial Info
Start Date :
October 19 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 19 2022
Estimated Enrollment :
17 Patients enrolled
Trial Details
Trial ID
NCT05286658
Start Date
October 19 2021
End Date
July 19 2022
Last Update
February 13 2024
Active Locations (2)
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1
University of Wisconsin
Madison, Wisconsin, United States, 53705
2
Medical College of Wisconsin
Milwaukee, Wisconsin, United States, 53226