Status:
ACTIVE_NOT_RECRUITING
Critical Illness Myopathy and Trajectory of Recovery in AKI Requiring CRRT
Lead Sponsor:
University of Iowa
Conditions:
Acute Kidney Injury
Critical Illness Myopathy
Eligibility:
All Genders
18-89 years
Brief Summary
The purpose of this study is to determine whether patients with acute kidney injury requiring renal replacement therapy have a higher incidence of muscle wasting than controls and whether the course o...
Detailed Description
Acute kidney injury (AKI), the abrupt loss of kidney function, is a common complication that affects more than half of all intensive care unit (ICU) admissions, and it is associated with substantially...
Eligibility Criteria
Inclusion
- \>18 years old
- AKI requiring CRRT, with enrollment within 48 hours of CRRT initiation
Exclusion
- ICU admission for \>7 days
- RRT of any kind at any time prior to ICU admission
- Chronic kidney disease (CKD) with estimated glomerular filtration rate \<20 mL/min/1.73 m2 as calculated by the 2021 CKD-EPI equation
- underlying muscle disorders or muscle atrophy such as quadriplegia or hemiplegia, stroke with residual motor deficits, end-stage liver disease, active alcohol use disorder, active malignancy (other than non-melanoma skin cancer) within 1 year, burns, or other baseline neuromuscular disease
- pregnancy
- concomitant use of other extracorporeal support devices such as ventricular assist devices or extracorporeal membrane oxygenation
- anticipated inability to engage in weight-bearing testing after discharge (e.g., trauma or orthopedic surgery)
- subjects will be ineligible for outpatient testing if they remain on RRT in the week prior to the research appointment
Key Trial Info
Start Date :
November 29 2021
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 30 2024
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT05287204
Start Date
November 29 2021
End Date
December 30 2024
Last Update
March 28 2024
Active Locations (3)
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1
University of Iowa
Iowa City, Iowa, United States, 52242
2
University of Kentucky
Lexington, Kentucky, United States, 40506
3
University of New Mexico
Albuquerque, New Mexico, United States, 87106