Status:
RECRUITING
The Efficacy of Aspirin Combined With Hydroxychloroquine Treatment in High Risk Pregnancies for Preeclampsia
Lead Sponsor:
Yoo-min Kim
Collaborating Sponsors:
Ministry of Health & Welfare, Korea
Conditions:
Preeclampsia
Eligibility:
FEMALE
19-50 years
Phase:
PHASE3
Brief Summary
This study is prospective, single arm group ,open label, and multicenter trial (with two parallel-group \[Hydroxychloroquine 200mg with Aspirin 100mg or Aspirin 100mg\])
Detailed Description
This study is prospective, open label, and multicenter trial \[Hydroxychloroquine 200mg with Aspirin 100mg\] The study population consists of the singleton pregnancy at high risk for preeclampsia who...
Eligibility Criteria
Inclusion
- The singleton pregnant women aged from 19 to 50 years
- Includes at least one factors of the below
- ① History of preeclampsia
- ② History of fetal growth restriction
- ③ History of intrauterine fetal death
- Women who have agreed to enroll in the study and given their informed consent
Exclusion
- Indication to a treatment according to the severe cardiovascular, immune, respiratory, gastrointestinal/liver and biliary system, kidney and urinary system, nervous system, musculoskeletal system, psychiatric, infectious disease and malignancy (However, the participation of the trial is allowed by the investigator based on medically necessary.)
- Previous inclusion in other intervention study within 3 months of screening (except for non-interventional observational studies)
- Major malformation of the fetus is diagnosed at 11-13 weeks of gestation
- Elevated blood concentrations of creatinine more than double the normal value
- Elevated blood concentrations of liver transaminases (AST(GOT) or ALT(GPT)) more than three times the normal value
- Conditions related with aspirin treatment
- Previous exposure within 28 days of screening
- Previous NSAID exposure within 28 days of screening
- Bleeding disorder (von Willebrand's disease, peptic ulceration)
- Hypersensitivity to aspirin
- Conditions related with hydroxychloroquine treatment
- Previous exposure within 28 days of screening
- Hypersensitivity to hydroxychloroquine and 4-aminoquinoline compounds
- Maculopathy
- Medications that has potential for visual disturbance
- Women who have potential for changes in the retina or visual impairment by 4-aminoquinoline compounds
- Galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption
- Prolonged QT interval on EKG (congenital or acquired) or The risk factors of QT prolongation (heart failure, arrhythmia, myocardial ischemia)
- Low level of potassium in the blood
- Low level of magnesium in the blood
- Not suitable for participant based on medical evidence by investigator
Key Trial Info
Start Date :
May 31 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2026
Estimated Enrollment :
58 Patients enrolled
Trial Details
Trial ID
NCT05287321
Start Date
May 31 2022
End Date
December 31 2026
Last Update
December 30 2024
Active Locations (1)
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1
Chung-Ang University Hospital
Seoul, South Korea, 06973