Status:
UNKNOWN
Analgesic Effect of Intraoperative Intravenous S-Ketamine During Total Knee Arthroplasty Surgery
Lead Sponsor:
Ling Dong
Conditions:
Postoperative Pain, Acute
Anaesthetic
Eligibility:
All Genders
65-90 years
Phase:
PHASE4
Brief Summary
Severe acute pain after total knee arthroplasty surgery has multiple implications for hospitals and patients, monopolising resources and affecting the quality of life. S-ketamine inhibits N-methyl-d-a...
Detailed Description
Total knee arthroplasty surgery is considered a cost-effective therapy for end-stage knee osteoarthritis (KOA). With an ageing population and rising rates of obesity in the world, knee joint replaceme...
Eligibility Criteria
Inclusion
- ASA physical statusI-III;
- Patients understood the study in detail and voluntarily signed the informed consent before the study;
- Patients to be treated with total knee arthroplasty Surgery under General anesthesia;
- Elderly patients(≥65y),regardless of gender;
- Patients can communicate normally;
- Patients who have no contraindications to drugs such as midazolam,fentanyl,s-ketamine.
- 18 kg/m2 ≤BMI≤30 kg/m2;
Exclusion
- Increased intracranial or intraocular pressure;
- severe hypertension;
- unwillingness the study;
- severe psychiatric disease and mental system diseases;
- severe respiratory diseases;
- hyperthyroidism;
- liver and kidney dysfunction;
- alcohol or drug abuse;
- allergy to midazolam,fentanyl,s-ketamine.
Key Trial Info
Start Date :
April 19 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2024
Estimated Enrollment :
144 Patients enrolled
Trial Details
Trial ID
NCT05289050
Start Date
April 19 2022
End Date
December 1 2024
Last Update
February 28 2023
Active Locations (1)
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1
Qianfoshan Hospital, The First Hospital affiliated of Shandong First Medical University
Jinan, Shandong, China, 250000