Status:
RECRUITING
Diminishing Accelerated Long-term Forgetting in Mild Cognitive Impairment
Lead Sponsor:
University of Dublin, Trinity College
Collaborating Sponsors:
Alzheimer's Association
Conditions:
Mild Cognitive Impairment
Memory Impairment
Eligibility:
All Genders
50+ years
Phase:
PHASE1
PHASE2
Brief Summary
This study is designed as a prospective, double-blind, placebo-controlled, randomized parallel-group study that will be completed at the clinical research facility at St. James' Hospital and at Trinit...
Detailed Description
Patients 50 years of age and above with amnestic mild cognitive impairment (aMCI), will be recruited to the memory clinic at St. James and the Memory Assessment and Support Service Tallaght University...
Eligibility Criteria
Inclusion
- ≥50 years
- Diagnosis of probable aMCI or mild AD
- Montreal Cognitive Assessment between 18-25
- Mini Mental State Examination score \>21
- Stable AChl medication \>3 months
- Adequate visual and auditory acuity
- Capacity to understand and sign informed consent
Exclusion
- Any cause of cognitive decline or dementia that is not Alzheimer's disease related including parkinsonism related dementias, vascular dementia, fronto-temporal dementia.
- Enrolment in an ongoing investigational medicinal product study
- History in the past 2 years of epileptic seizures
- Any current major psychiatric disorder
- Evidence of brain damage, including significant trauma, stroke, hydrocephalus, intellectual disability, or serious neurological disorder.
- History of alcoholism or drug abuse within the last 12 months
- Medical devices not eligible for MRI scanning
Key Trial Info
Start Date :
September 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 1 2027
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT05289804
Start Date
September 1 2022
End Date
January 1 2027
Last Update
March 27 2025
Active Locations (1)
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1
TCIN
Dublin, Ireland, Dublin 2