Status:
UNKNOWN
Efficacy and Safety Study of Medical Thoracoscope Cryotherapy Combined Standard First-line Treatment of Advanced Non-small Cell Lung Cancer and Malignant Pleural Effusion
Lead Sponsor:
Qianfoshan Hospital
Conditions:
Non Small Cell Lung Cancer
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
This study intends to investigate the efficacy and safety of medical thoracoscopic cryotherapy combined with standard first-line treatment of advanced non-small cell lung cancer with malignant pleural...
Eligibility Criteria
Inclusion
- 18-75 years old;
- Non-small cell lung cancer with pleural metastasis confirmed by histopathology or cytology;
- ECOG score 0-1;
- Cardiopulmonary function can tolerate painless thoracoscopic examination;
- Patients who underwent medical thoracoscopy for pleural effusion at first diagnosis and underwent medical thoracoscopy cryotherapy at the same time of biopsy were also included in the study. Non-small cell lung cancer was confirmed by pathological results;
- All subjects or their guardians must sign the informed consent before entering the study.
Exclusion
- Expected survival \<2 months;
- Hemoglobin \<110g/L, white blood cell count \<3×109/L, neutrophil \<2.0×109/L, platelet \<100×109/L;
- severe cardiac insufficiency, abnormal liver and kidney function (blood test results of transaminase and creatinine \> 1.5 times the normal upper limit);
- have received chemotherapy or anti-angiogenic drugs (such as bevacizumab, endu, anlotinib, etc.);
- History of radiotherapy;
- history of intrathoracic local treatment;
- multiple serous cavity effusion, or bilateral pleural effusion;
- patients allergic to erythromycin;
- the lung cannot be reopened.
Key Trial Info
Start Date :
April 6 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2024
Estimated Enrollment :
141 Patients enrolled
Trial Details
Trial ID
NCT05291403
Start Date
April 6 2022
End Date
December 31 2024
Last Update
November 18 2023
Active Locations (1)
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1
Department of Respiratory, The First Affiliated Hospital of Shandong First Medical University
Jinan, Shandong, China, 250014