Status:
COMPLETED
Carbon Dioxide (CO2) and Cognitive Impairment
Lead Sponsor:
Rutgers, The State University of New Jersey
Conditions:
Healthy
Eligibility:
All Genders
18-30 years
Phase:
NA
Brief Summary
The purpose of the study is to better understand the biological mechanisms of carbon dioxide (CO2)-induced cognitive impairments.
Detailed Description
Participants will complete 2 study visits. Each study visit will consist of a 2.5-hour exposure session. Concentrations of CO2 during the exposure session will be either 600 ppm (control) or 2500 ppm ...
Eligibility Criteria
Inclusion
- History of COVID-19 vaccination
- Weigh at least 110 pounds
Exclusion
- Colorblindness
- Inability to hear verbal instructions
- Cardiovascular disease, including a history of stroke
- Diabetes requiring the use of insulin
- Pregnancy
- Current asthma (an asthma attack within the past five years)
- Medications for or history of anxiety disorder diagnosis or panic attacks
- Medications which may affect cognition such as beta-blockers and CNS depressants
- Temporary Exclusion Criteria
- Respiratory symptoms in the previous four weeks
- Use of sedating cold/allergy medications in the previous week
- Use of marijuana in the previous week
- Consumption of alcohol in the previous 24 hours
- Additional Exclusion Criteria for Subjects undergoing the fMRI scan:
- History of head trauma or neurosurgery or neurological disorder
- Ferrous metal implanted in or on the body, electrical devices such as a pacemaker, nonremovable ferrous jewelry
- Surgical pins or plates above the neck
- History of eye injury involving metallic materials, shavings in eyes, or welding without a face mask
- Lead or iron tatoos
- Claustrophobia
- Back problems that would prevent the subject from laying still comfortably for up to 90 minutes
- Additional Exclusion Criteria for Subjects undergoing CAIM
- Current or recent contact lens use
Key Trial Info
Start Date :
July 14 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 20 2025
Estimated Enrollment :
27 Patients enrolled
Trial Details
Trial ID
NCT05292378
Start Date
July 14 2022
End Date
March 20 2025
Last Update
July 25 2025
Active Locations (1)
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1
Rutgers - EOHSI
Piscataway, New Jersey, United States, 08854