Status:
COMPLETED
Beta 2 Adrenergic Stimulation vs Cold Exposure to Activate Human Brown Adipose Tissue
Lead Sponsor:
University Hospital, Basel, Switzerland
Conditions:
Thermogenesis
Eligibility:
All Genders
18-40 years
Phase:
EARLY_PHASE1
Brief Summary
The purpose of the study is to asses brown adipose tissue activity in humans after intravenous administration of the selective beta-2-adrenergic agonist fenoterol as compared to the natural activator ...
Detailed Description
The activation of brown adipose tissue in response to beta-2-adrenergic stimulation as compared to cold exposure will be studied in an open-label, cross-over trial in healthy volunteers with random se...
Eligibility Criteria
Inclusion
- BMI 18,5-23 kg/m2 or 30-35 kg/m2
Exclusion
- History or signs of any medical or psychological condition
- pregnancy or lactation
- medications except prescription free analgesics and contraceptives
- habitual alcohol or tobacco use
- weight change \>5% within prior 3 months
- Resting heart rate \>85 bpm
- Systolic blood pressure \>140 mmHg or diastolic blood pressure \<50 mmHg
- Presence of following ECG changes: ST-segment deviations, QTc \>500ms, signs of pre-excitation
- Hyper- or Hypothyroidism
- inability to follow study procedures
- Enrolment of the investigator, his/her family members, employees and other dependent persons
- hypersensitivity to cold
- enrolment into study with ionizing radiation within prior 12 months.
- Cold induced thermogenesis of less than 5% basal metabolic rate and normal weight or cold induced thermogenesis of more than 5% and overweight (determined during screening visit)
Key Trial Info
Start Date :
April 27 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 6 2023
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT05294965
Start Date
April 27 2022
End Date
March 6 2023
Last Update
September 26 2023
Active Locations (1)
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1
University Hospital Basel, Dept. of Endocrinology
Basel, Switzerland