Status:
ACTIVE_NOT_RECRUITING
Vascular Aging and Lp299v Study
Lead Sponsor:
Medical College of Wisconsin
Conditions:
Vascular Aging
Eligibility:
All Genders
50-99 years
Phase:
NA
Brief Summary
Emerging data suggest the gut microbiota regulates multiple mechanisms related to vascular aging, but no intervention targeting the gut microbiota has been tested in older adults without cardiovascula...
Detailed Description
Multiple lines of evidence suggest that aging results in significant changes in the composition and metabolism of the gut microbiota that accelerate mechanisms responsible for vascular aging. Recent w...
Eligibility Criteria
Inclusion
- Ages 50-99 years
- For women: 12 months or more since last menstruation
Exclusion
- Systolic Blood Pressure ≥ 130 mmHg or Diastolic BP ≥ 80mmHg
- Currently taking pharmacological therapies for hypertension, dyslipidemia, or glucose control
- Diabetes (type 1 or 2) or glycosylated hemoglobin ≥ 5/7%
- LDL Cholesterol \> 160 mg/dL or Total Cholesterol \> 200 mg/dL
- Cigarette use within 3 years of enrollment
- Average of \> 7500 steps per day as measured during screening period
- Received probiotics, prebiotics, and/or antibiotics within six weeks of enrollment
- History of chronic renal insufficiency, liver dysfunction, or cancer besides non-melanoma skin carcinomas or localized prostate cancer requiring systemic treatment within 3 years of enrollment
- History of inflammatory rheumatic diseases known to increase atherosclerotic cardiovascular risk (e.g. rheumatoid arthritis, systemic lupus erythematosus)
- Known history of cognitive impairment or inability to follow study procedures
- GI tract illnesses such as short gut syndrome, inflammatory bowel disease, or an ileostomy
- Daily alcohol use
Key Trial Info
Start Date :
February 1 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 22 2027
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT05296395
Start Date
February 1 2023
End Date
September 22 2027
Last Update
April 27 2025
Active Locations (1)
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1
Medical College of Wisconsin
Milwaukee, Wisconsin, United States, 53226