Status:
UNKNOWN
Effects of Repeated Intravenous Anesthesia With Propofol on the Postoperative Neurological Function of Patients Undergoing Hysteroscopic Surgery
Lead Sponsor:
The Third Xiangya Hospital of Central South University
Conditions:
PND
Anesthesia
Eligibility:
FEMALE
18-45 years
Brief Summary
Perioperative neurocognitive disorders（PND） is a common complication during the perioperative period, which affects the patient's rehabilitation and quality of life. Animal studies have found that rep...
Detailed Description
Central nervous system dysfunction is a common complication during the perioperative period, which affects the patient's rehabilitation and quality of life. Animal studies have found that repeated and...
Eligibility Criteria
Inclusion
- Clinical diagnosis of intrauterine adhesions
- Need hysteroscopic surgery due to intrauterine adhesions
- Women of childbearing age who wish to have children
Exclusion
- Those with contraindications to general anesthesia or those who had a history of anesthesia accident
- Those who are known or suspected to be allergic or contraindicated to propofol injection excipients
- Patients with acute upper respiratory tract infection, asthma attack, or acute severe laryngeal disease
- History of gastrointestinal disease: gastrointestinal retention, active bleeding, which may lead to reflux aspiration, etc.
- Complicated medical history of craniocerebral injury, intracranial hypertension, stroke, cerebrovascular accident
- Respiratory insufficiency, obstructive pulmonary disease
- Uncontrolled hypertension, hypotension, and diabetes
- Severe arrhythmia, heart failure, unstable angina, myocardial infarction
- Severe liver dysfunction or severe renal insufficiency
- History of alcoholism or drug dependence
- Abuse or long-term use of narcotic, sedative, and analgesic drugs
- Those who have a history of mental illness
- Participated in any other clinical investigators within 1 month before screening
- Subjects who are considered by the investigator to have any other factors that are not suitable for participating in this research
Key Trial Info
Start Date :
April 1 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
June 1 2024
Estimated Enrollment :
258 Patients enrolled
Trial Details
Trial ID
NCT05297682
Start Date
April 1 2022
End Date
June 1 2024
Last Update
May 10 2022
Active Locations (1)
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1
The Third Xiangya Hospital
Changsha, Hunan, China, 410013