Status:
UNKNOWN
Impact of Hypertonic Saline Solution on Acute Decompensated Heart Failure
Lead Sponsor:
University of Monastir
Conditions:
Acute Decompensated Heart Failure
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Acute decompensated heart failure (HF) is one of the most common cardiologic issues in emergency departments. Loop diuretics have long been recognized as the key for the treatment of Acute Decompensa...
Detailed Description
In the era of the emergence of novel therapies for advanced Chronic Heart Failure , the use of HSS as a therapeutic adjunct to i.v. loop diuretics still needs to be explored on a larger scale, in part...
Eligibility Criteria
Inclusion
- Patients with 18 years of age or older
- ADHF with congestive symptoms, laboratory(BNP) and echocardiographic criteria
- NYHA ≥II(New York Heart Association functional classification)
- Creatinine clearance≤60ml/mn (MDRD) or level of creatinine \>150 µg/ml)
- BNP levels on admission ≥400 pg/mL
Exclusion
- age \< 18 years
- NYHA class \< II
- Patients with acute coronary syndrome, pulmonary thromboembolism, cardiac tamponade, pericarditis, those on dialysis; patients with chronic liver disease, pleuropneumonia, cerebral vascular disease, cancer, uncompensated diabetes, patients requiring pacemaker and concomitant other important comorbidity
- Signs of hemodynamic instability, respiratory distress, coma
Key Trial Info
Start Date :
July 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2023
Estimated Enrollment :
600 Patients enrolled
Trial Details
Trial ID
NCT05298098
Start Date
July 1 2018
End Date
September 1 2023
Last Update
May 16 2023
Active Locations (1)
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1
Emergency department of university hospital Fattouma Bourguiba of Monastir Monastir, Monastir Tunisia
Monastir, Tunisia, 5000