Status:
COMPLETED
Determining the Feasibility of Outpatient Parenteral Antibiotic Therapy for Persons Who Inject Opioids
Lead Sponsor:
Washington University School of Medicine
Conditions:
Opioid Use Disorder
Eligibility:
All Genders
18-100 years
Phase:
NA
Brief Summary
Patients with a history of injection drug use are historically excluded from home outpatient parenteral antibiotic therapy programs. Recent small pilot programs have demonstrated that these patients m...
Eligibility Criteria
Inclusion
- English speaking males and females
- 18-100 years of age
- Being considered for discharge from Barnes-Jewish Hospital on OPAT\* (PICC/Midline only) for a serious injection related infection including; endocarditis, osteomyelitis, discitis, septic arthritis, epidural abscess, or S. aureus bacteremia. \*Note that outside of this protocol patients with a history of substance use disorder are considered for discharge on OPAT to skilled nursing facilities or other health-care locations such as BJH extended care. Patients being considered for discharge on OPAT to any of these locations are eligible for inclusion.
- History of injection opioid use within the last 1 year
- Evaluated by the joint toxicology/psychiatry addiction medicine consult service during the current inpatient admission
- Started or maintained on medications for opioid use disorder (MOUD) of either methadone, buprenorphine or buprenorphine-naloxone during admission to Barnes-Jewish Hospital
- Have a scheduled follow-up for continuation of medications for opioid use disorder in place prior to discharge. For patients on methadone this should include a scheduled appointment at a methadone clinic, or for patients on buprenorphine this can include a plan for ongoing buprenorphine/ buprenorphine-naloxone based therapy at the Washington University Infectious Diseases Clinic.
- Have met with a health coach or a member of the Bridge To Health team during their inpatient hospitalization and agree to ongoing supportive counseling after discharge.
- Be willing and able to attend in-person clinic visits within 60 days post-discharge at the Washington University Infectious Diseases Clinic.
- Have a working phone number with active voicemail, running water and electricity.
Exclusion
- Prisoner status
- Unable to provide own informed consent
- Current homelessness
- Other house-hold members reported as having active untreated substance use disorders
- Unable to attend outpatient appointments. This may include patients who are from rural areas where transportation vouchers may not provide sufficient means of making it to follow-up appointments, or other disability that would preclude transportation (paralysis, broken limbs) where the patient is unable to provide specific details as to how they would arrive at clinic appointments.
Key Trial Info
Start Date :
March 16 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 19 2025
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT05300581
Start Date
March 16 2022
End Date
December 19 2025
Last Update
December 29 2025
Active Locations (1)
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1
Washington Univeristy
St Louis, Missouri, United States, 63110