Status:

ENROLLING_BY_INVITATION

Sensitivity of the NIH Toolbox to Stimulant Treatment in Intellectual Disabilities

Lead Sponsor:

University of California, Davis

Collaborating Sponsors:

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Conditions:

Intellectual Disability

Fragile X Syndrome

Eligibility:

All Genders

6-24 years

Phase:

PHASE1

Brief Summary

This study is a randomized, double-blind, placebo-controlled, crossover trial of extended-release liquid methylphenidate (XRMPH) to evaluate the sensitivity of the NIH Toolbox Cognition Battery (NIHTB...

Eligibility Criteria

Inclusion

  • IQ below 80
  • Mental age 3.0 or higher (Stanford Binet)
  • Diagnosis of Intellectual Disability
  • Diagnosis of ADHD
  • Ability to complete valid NIHTB-CB tests at screening/baseline

Exclusion

  • stimulant use within 2 weeks prior to randomization
  • history of a sensitivity reaction to stimulants
  • presence of significant comorbid psychiatric or medical disorder/illness deemed by the site physician as inappropriate for stimulant use (uncontrolled epilepsy, bipolar disorder, psychosis, severe OCD, hypertension, tachycardia hypertension, failure to thrive, psychosis for example)
  • a household resident with a current substance abuse disorder

Key Trial Info

Start Date :

February 1 2023

Trial Type :

INTERVENTIONAL

Allocation :

ESTIMATED

End Date :

September 29 2026

Estimated Enrollment :

68 Patients enrolled

Trial Details

Trial ID

NCT05301361

Start Date

February 1 2023

End Date

September 29 2026

Last Update

December 15 2025

Active Locations (3)

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Page 1 of 1 (3 locations)

1

UC Davis MIND Institute

Sacramento, California, United States, 95817

2

Rush University

Chicago, Illinois, United States, 60612

3

Cincinnati Children's Hospital

Cincinnati, Ohio, United States, 45229