Status:
UNKNOWN
Breast CANcer Risk Assessment in Younger Women: BCAN-RAY
Lead Sponsor:
Manchester University NHS Foundation Trust
Conditions:
Breast Cancer Female
Eligibility:
FEMALE
30-39 years
Brief Summary
The overarching aim of the proposed research is to develop a comprehensive breast cancer risk assessment strategy for women aged 30-39 years. There are three main objectives to the study. Objective ...
Detailed Description
Breast cancer (BC) is the most common cause of female cancer death worldwide. Incidence and mortality rates rise exponentially from age 30-50 (figure; CRUK 2021) and BC is the most common of any cause...
Eligibility Criteria
Inclusion
- 1 Inclusion Criteria 4.1.1 Main study
- The following criteria must be met for entry to the main case control study:
- 1.1.1 Cases
- Born biologically female
- Aged 30-39 years when diagnosed with breast cancer
- Able to provide informed consent
- 1.1.2 Controls
- Born biologically female
- Aged 30-39 years
- Able to provide informed consent
- 1.2 Acceptability Substudy All control participants that are eligible for the main study are eligible for inclusion in the acceptability substudy.
- 1.3 DNA methylation substudy
- Case participants will only be eligible for the DNAme substudy if they fulfill all eligibility criteria for the main study and the following inclusion criterion:
- • Yet to receive any systemic therapy for early breast cancer (chemotherapy, endocrine therapy or targeted therapy eg trastuzumab (Herceptin))
- All control participants are eligible for the DNAme substudy if eligibility criteria are met for the main study.
Exclusion
Key Trial Info
Start Date :
January 31 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
May 31 2025
Estimated Enrollment :
1000 Patients enrolled
Trial Details
Trial ID
NCT05305963
Start Date
January 31 2023
End Date
May 31 2025
Last Update
July 10 2023
Active Locations (1)
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1
Wythenshawe Hospital
Manchester, Greater Manchester, United Kingdom, M23 9LT